While withdrawal symptoms from typical antipsychotics are generally mild and self-limiting, clozapine discontinuation can trigger a severe clinical picture characterized by rapid-onset agitation, delirium, and psychosis. Research into three specific case reports highlights that these symptoms often manifest within days of stopping the medication. Patients may experience a clouding of consciousness, disorientation, and even physical complications like profuse diaphoresis, inco

Delirium remains a significant challenge in intensive care units, affecting nearly 32% of all critically ill patients and surging as high as 91% for those on mechanical ventilation. While haloperidol has traditionally served as the first-line treatment, its association with distressing extrapyramidal side effects and severe sedation has led researchers to explore safer alternatives. A recent randomized controlled trial published in Neurocritical Care  investigated whether que

This mixed-method systematic review by Reman et al. (2023) investigates the significant mental health burden associated with female genital mutilation/cutting (FGM/C). By analyzing 14 studies published between 2010 and 2020, the researchers found that women who have undergone FGM/C experience a significantly higher prevalence of psychological disorders compared to those who have not. The primary clinical diagnoses identified include post-traumatic stress disorder (PTSD), depr

Conversion disorder—now termed Functional Neurological Disorder (FND) —has long been viewed through a pessimistic lens, particularly when symptoms persist over time. A major 2025 systematic review and meta-analysis in BMJ Neurology Open  challenges that assumption by examining whether symptom chronicity actually limits treatment response . Drawing on 63 studies (27 included in meta-analyses, 885 patients), the authors evaluated outcomes across functional motor disorders,...