Understanding Voices from Within Auditory verbal hallucinations (AVH)—hearing voices without external sound—are among the most defining yet puzzling symptoms of schizophrenia. This open-access study by Whitford et al. (2025) explores a long-standing theory: that such voices arise when the brain mistakes inner speech for external sound. Normally, a “corollary discharge” mechanism tells the brain, “This sound came from me.”  If that signal fails, self-generated thoughts may be

Background Ketamine’s rapid antidepressant effects have fueled growing off-label use in hospitals and private clinics. Yet its true efficacy—especially when compared with active psychoactive placebos—has remained uncertain. The KARMA-Dep 2  randomized clinical trial, led by Ana Jelovac and colleagues at Trinity College Dublin, sought to determine whether serial ketamine infusions improve depressive symptoms beyond those seen with midazolam , a sedative used as an active contr

This study by Popa, A.V., et al. (2025) investigated the factors contributing to the 17-year life expectancy gap  between individuals with schizophrenia and the general population, based on a 10-year follow-up of a Romanian cohort. The study found a significant burden of premature mortality , with the mean age at death in the cohort being 58.97 years , compared to a general population life expectancy of 75.94 years, reflecting a 17-year reduction in life expectancy. The stand

Paris’ 2004 paper, “Is Hospitalization Useful for Suicidal Patients with Borderline Personality Disorder?”  (Journal of Personality...